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KMID : 0380020060210020151
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Korean Journal of Biotechnology and Bioengineering
2006 Volume.21 No. 2 p.151 ~ p.156
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Stability of Vitamin-C Inclusion Complexes Prepared using a Solvent Evaporation Method
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Yang Jun-Mo
Lee Yun-Kyung
Kim Eun-Mi
Jung In-Il
Ryu Jong-Hoon
Lim Gio-Bin
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Abstract
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Vitamin-C is one of the typical bioactive substances widely used in the cosmetic and pharmaceutical applications. It is well known that the bioavailability of vitamin-C decreases with time because it is spontaneously oxidized in the presence of oxygen. In this study, vitamin-C inclusion complexes were prepared by formulating vitamin-C with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) to protect vitamin-C from being oxidized. Vitamin-C inclusion complexes were prepared by a solvent evaporation method using a rotary evaporator and various solvents of different dielectric constant such as ethanol, methanol and distilled deionized water to investigate the effect of solvent polarity on the stability of vitamin-C. To estimate the stability of inclusion complexes, samples were stored in a 50 mM phosphate buffer solution of pH 7.0 for 24 hours at 25 ± 0.1℃ and the degradation rate of vitamin-C was calculated using a high performance liquid chromatography. The stability of vitamin-C was observed to improve with the increase of solvent polarity.
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KEYWORD
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Vitamin-C, cyclodextrin, inclusion complex, stabilization, solvent evaporation
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